First-line temsirolimus improves survival in advanced renal cell carcinoma
American researchers have reported increased survival with temsirolimus (Torisel) compared with the standard treatment for this disease, interferon alpha, in patients with advanced renal cell carcinoma (RCC), in a study published today in The New England Journal of Medicine.
In this multicenter, phase III trial, 626 patients with previously untreated, advanced RCC received either temsirolimus, interferon alpha, or both as combination therapy.
Overall survival and progression-free were significantly longer in patients receiving temsirolimus, compared with patients receiving interferon alone. There was no significant difference in overall survival between patients in the interferon group versus the combination therapy group. In addition, there were significantly fewer serious adverse events in the tesirolimus group versus the interferon alpha group.
Author’s conclusions: ‘As compared with interferon alfa, temsirolimus improved overall survival among patients with metastatic renal-cell carcinoma and a poor prognosis. The addition of temsirolimus to interferon did not improve survival.’
Note: Wyeth filed an application with the U.S. Food and Drug Administration in November 2006 for approval to market temsirolimus for the treatment of advanced renal cell carcinoma. A decision is expected shortly (July 2007).
Source: http://content.nejm.org/cgi/content/short/356/22/2271
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